File:The preference for sugar over sweetener depends on a gut sensor cell.pdf
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DescriptionThe preference for sugar over sweetener depends on a gut sensor cell.pdf |
English: Guided by gut sensory cues, humans and animals prefer nutritive sugars over non-caloric sweeteners, but how the gut steers such preferences remains unknown. In the intestine, neuropod cells synapse with vagal neurons to convey sugar stimuli to the brain within seconds. Here, we found that cholecystokinin (CCK)-labeled duodenal neuropod cells differentiate and transduce luminal stimuli from sweeteners and sugars to the vagus nerve using sweet taste receptors and sodium glucose transporters. The two stimulus types elicited distinct neural pathways: while sweetener stimulated purinergic neurotransmission, sugar stimulated glutamatergic neurotransmission. To probe the contribution of these cells to behavior, we developed optogenetics for the gut lumen by engineering a flexible fiberoptic. We showed that preference for sugar over sweetener in mice depends on neuropod cell glutamatergic signaling. By swiftly discerning the precise identity of nutrient stimuli, gut neuropod cells serve as the entry point to guide nutritive choices. |
Date | 13 January 2022 |
Source | https://www.nature.com/articles/s41593-021-00982-7 |
Author | Kelly L. Buchanan, Laura E. Rupprecht, M. Maya Kaelberer, Atharva Sahasrabudhe, Marguerita E. Klein, Jorge A. Villalobos, Winston W. Liu, Annabelle Yang, Justin Gelman, Seongjun Park, Polina Anikeeva & Diego V. Bohórquez |
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This file is licensed under the Creative Commons Attribution 4.0 International license. | ||
https://creativecommons.org/licenses/by/4.0 CC BY 4.0 Creative Commons Attribution 4.0 truetrue |
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current | 10:39, 24 January 2022 | 1,239 × 1,645, 29 pages (12.7 MB) | Koavf (talk | contribs) | Uploaded a work by Kelly L. Buchanan, Laura E. Rupprecht, M. Maya Kaelberer, Atharva Sahasrabudhe, Marguerita E. Klein, Jorge A. Villalobos, Winston W. Liu, Annabelle Yang, Justin Gelman, Seongjun Park, Polina Anikeeva & Diego V. Bohórquez from https://www.nature.com/articles/s41593-021-00982-7 with UploadWizard |
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Publisher | Springer US |
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Software used | Springer |
File change date and time | 21:30, 4 January 2022 |
Date and time of digitizing | 21:29, 4 January 2022 |
Date metadata was last modified | 21:30, 4 January 2022 |
Copyright status | Copyrighted |
Identifier | doi:10.1038/s41593-021-00982-7 |
Encrypted | no |
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Version of PDF format | 1.4 |